X-linked hypophosphatemia (XLH) can cause rickets in children. Rickets is the softening and weakening of the bones in children caused by deficiencies in vitamin D, calcium, or phosphate before the growth plate closes.

Cera, living with XLH

Rickets in children is caused by low serum phosphorus in the body. Early diagnosis of rickets can help doctors determine if XLH could be the underlying cause and provide the right treatment for your child.

Common symptoms of rickets are bowed legs, stunted growth, short stature, dental cavities, and bone pain. Bowed legs typically present when the child can bear weight on their legs and can lead to compounding complications as the child gets older.

Although rickets is a childhood disease, if left untreated, rickets can cause continuing complications such as osteomalacia in adulthood.

In clinical trials, CRYSVITA® (burosumab-twza) has been shown to help heal rickets and improve leg abnormalities in children with XLH.

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