Osteomalacia is the softening and weakening of the bones in children and adults caused by deficiencies in vitamin D, calcium, or phosphate. In osteomalacia, the weaking of the bones is independent of the growth plate and allows the bones to bend easily.

Aly and Sarah, living with XLH

Adults with X-linked hypophosphatemia (XLH) typically have osteomalacia, a weakening of the bones that can lead to fractures, especially in the feet, legs, and hips. Weakening of the bones is caused by low levels of phosphate that the bones need to grow strong. Fractures will typically present at a young age due to the ongoing effects of osteomalacia.

Osteomalacia can lead to overall decline in physical and
emotional health.
Early detection of osteomalacia will help slow down the compounding symptoms through the development of the right treatment plan with a doctor.

In clinical trials, CRYSVITA® (burosumab-twza) has been shown to help heal fractures and osteomalacia in adults with XLH.

See more results for adults